Cancer spread is increased by a high fat diet, new study shows

A new study which was partly funded by UK charity Worldwide Cancer Research and headed by Professor Salvador Aznar Benitah,
at the Institute for Research in Barcelona (IRB) have identified for the first time a specific
protein called CD36 on cancer cells which have the ability to metastasize. CD36,
that  is responsible for taking up fatty acids, is found in the cell membranes of tumours.
The unique activity and dependence on fatty acids distinguishes metastasis-initiating cells from other tumour cells.

Cancer is most deadly when it has begun to spread as successful treatment is far harder.
Because of this scientists around the globe are  trying to understand how the process occurs and develop new ways to stop it.

Professor Benitah’s team found CD36 was present on metastatic cancer cells from patients with a range of
different tumours.
To confirm its vital role in cancer spread, they added CD36 to non-metastatic cancer cells
which then caused the cells to become metastatic.

“Although we have not yet tested this in all tumour types, we can state that CD36 is a general marker of metastatic cells,
the first I know of that is generally specific to metastasis,” says Professor Benitah,
Head of the Stem Cell and Cancer Lab at IRB Barcelona.

“We expect this study to have a big impact on the scientific community and to further advances in metastasis research,
and we hope to be able to validate the potential of CD36 as an anti-metastasis treatment. Things like this don’t happen every day.”

The study

The researchers next looked at what role  fat intake played on cancer spread.
They provided mice with a high fat diet then injected them with a type of human oral cancer.
The high fat diet caused 50% more mice to have larger and more frequent metastases.

They decided to test a specific saturated fatty acid called palmitic acid,
a major component of animal and vegetable fats and present at high levels in palm oil
which has widespread use in household products from peanut butter and processed food to toothpaste.
The scientists treated human oral tumours with palmitic acid for two days then injected them into mice fed a standard diet.
The team observed that all the mice with CD36 developed cancer spread compared to only half when not treated with palmitic acid.

“In mice inoculated with human tumour cells, there appears to be a direct link between fat intake and an increase
in metastatic potential through CD36. More studies are needed to unravel this intriguing relationship,
above all because industrialised countries are registering an alarming increase in the consumption of saturated fats and sugar,
” warns Professor Benitah. ”

Fat

is fundamental for the function of the body, but a large intake can have an effect on health,
as already shown for some tumours such as colon cancer, and in metastasis, as we demonstrate here.”

Using mice with human oral cancer, they were next able to show that blocking  the protein CD36 completely prevented metastasis.
In mice with cancer cells that had already metastasised, CD36 blocking antibodies led to the
complete disappearence of metastases in 20% of the mice, whilst in the others it caused a climatic
reduction of 80-90% of metastases and reduced the size. Essentially, this was all achieved with no serious side effects.

The researchers are now developing new antibody-based therapeutics against CD36
that could potentially be appropriate to treat a range of cancers in patients in the future.

Dr Lara Bennett, Science Communications Manager at Worldwide Cancer Research said:
“We have been supporting Professor Benitah’s work for a number of years and it is fantastic
to now see these truly game-changing results. If the team are able to go on to develop this
antibody into a treatment for humans it could save thousands of lives every year.”

source: sciencedaily.com

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      • 25.02.2017 at 4:59
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        Whatever goods or items you have to guarantee, it’s vital
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      • 25.02.2017 at 6:30
        Permalink

        Despite the fact that it is a demand of all the broker agents,
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      • 25.02.2017 at 7:55
        Permalink

        For example, some plans define a weight restriction, just paying up to
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    • 23.02.2017 at 14:19
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      • 24.02.2017 at 10:00
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        So, to trade options successfully you have to discover an account and platform that complement your method.

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      • 24.02.2017 at 11:06
        Permalink

        Vans as well as various other motor vehicles considering less compared to this are classified as light
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      • 24.02.2017 at 12:22
        Permalink

        KEEP IN MIND most insurance providers will just approve
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      • 24.02.2017 at 12:42
        Permalink

        Porter Finance appreciates that there are low and high volume traders aiming
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      • 24.02.2017 at 13:26
        Permalink

        Theft, fraud and also late shipments have never been an issue, yet insurance coverage and also licenses were an obstacle, Pohl clarified.

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      • 24.02.2017 at 15:47
        Permalink

        Binary Options trading is not prohibited or illegal within Australia,
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      • 24.02.2017 at 16:34
        Permalink

        We are 100 % clear that, Banc De Binary like other regulated brokers is regulated in many nations example UK (Registration # 596375) France (Registration # 74412) Italy (Registration # 3614) Cyprus
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      • 24.02.2017 at 19:00
        Permalink

        Keep in mind that they don’t trade in US dollars but
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      • 24.02.2017 at 22:36
        Permalink

        There is a minimum withdrawal limit of $50, and an excellent quick withdrawal time
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      • 24.02.2017 at 22:36
        Permalink

        The majority of the Brokers are aware of this scenario and that
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      • 25.02.2017 at 0:07
        Permalink

        Responsibility for loss or harm to products en route is delegated to the seller,
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      • 25.02.2017 at 0:21
        Permalink

        An account can be opened without making a deposit, however trading
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      • 25.02.2017 at 2:01
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        Concerning: CSA Financier Alert: Unregistered binary choice platforms
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      • 25.02.2017 at 4:52
        Permalink

        Some disorders of carriage are imposed by statute as a result of the nature of the goods and/or
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      • 25.02.2017 at 7:16
        Permalink

        Technological advances over the last few years have equated to
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      • 25.02.2017 at 7:53
        Permalink

        As you may or might not understand, the Financial Conduct Authority (FCA) is charged with supervising and controling all financial service
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        Reply
      • 25.02.2017 at 8:45
        Permalink

        As a messenger it’s really important to have insurance policy that covers
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    • 24.02.2017 at 6:09
      Permalink

      Our Courier Insurance coverage features the included assurance
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    • 24.02.2017 at 7:19
      Permalink

      For various other insurance policy claims (excluding the
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      Reply
    • 24.02.2017 at 9:45
      Permalink

      You can then begin with your demo account instantly to obtain a feel of the system prior to trading with actual funds.

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    • 24.02.2017 at 10:22
      Permalink

      And binary options brokers are not just sites, but
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    • 24.02.2017 at 12:53
      Permalink

      Responsibility under products responsibility develops through statute, written agreement or common law.

      Reply
    • 24.02.2017 at 16:08
      Permalink

      All of us require an assisting hand from time to time, and
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      Reply
    • 24.02.2017 at 17:19
      Permalink

      So, we use Feefo, a completely independent third party business, to gather comments on every policy we
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      Reply
    • 24.02.2017 at 17:27
      Permalink

      As you can not discover a licensed business in your location,
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      Reply
    • 24.02.2017 at 18:11
      Permalink

      When it is due to its very own carelessness while the goods
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    • 24.02.2017 at 19:12
      Permalink

      Our costs will certainly ensure you get affordable pay for all automobiles utilized
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      Reply
    • 24.02.2017 at 19:21
      Permalink

      Option Number 1 – Transportation vehicle insurance policy – One type of vehicle insurance coverage
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      Reply
    • 24.02.2017 at 19:23
      Permalink

      You can typically discover this information, nevertheless, right on the brokers site,
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      Reply
    • 24.02.2017 at 19:36
      Permalink

      The following Binary Options brokers have a variety of various banking choices that
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      Reply
    • 24.02.2017 at 20:18
      Permalink

      The terms FOB destination and also FOB delivery point typically show a certain location at
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      Reply
    • 24.02.2017 at 20:44
      Permalink

      Remember however, that if stated dispensary caretaker went
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      Reply
    • 25.02.2017 at 0:09
      Permalink

      Riscx have several of the very best messengers insurance plan available
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    • 25.02.2017 at 0:10
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      One element in regards to you being a Canadian Binary Choice
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      Reply
    • 25.02.2017 at 2:05
      Permalink

      In order for US binary choices traders to avoid signing
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      Reply
    • 25.02.2017 at 2:28
      Permalink

      It isn’t really unlawful for any Binary Options broker to accept United States
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      Reply
    • 25.02.2017 at 3:41
      Permalink

      Assets – The more possessions a broker provides the much
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    • 25.02.2017 at 4:00
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      There are many different platforms out there, from popular
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    • 25.02.2017 at 5:20
      Permalink

      With low policy extras as well as strong degrees of cover available, we could supply you
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  • 20.02.2017 at 16:45
    Permalink

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      • 24.02.2017 at 8:21
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        All these are suggested by Fair Binary Options as an excellent location to trade,
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      • 24.02.2017 at 10:49
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      • 24.02.2017 at 12:01
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      • 24.02.2017 at 14:56
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      • 25.02.2017 at 0:30
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      • 25.02.2017 at 1:54
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      • 25.02.2017 at 5:00
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      • 25.02.2017 at 6:43
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        There are action buttons for the type of options Call/Put that you wish to trade, along with the amount to invest.

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      • 25.02.2017 at 7:42
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      • 25.02.2017 at 8:10
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